A human telomeric protein. Chong L, van Steensel B, Broccoli D, Erdjument-Bromage H, Hanish J, Tempst P, de Lange T.Science. 1995 Dec 8;270(5242):1663-7.
Western Blot (Cell lysate)
TERF1 polyclonal antibody (Cat # PAB6118) staining (2 ug/mL) of HeLa lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq
telomeric repeat binding factor 1,telomeric repeat binding protein 1