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Last updated: 2016/12/4
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DUSP10 polyclonal antibody

  • Catalog # : PAB6116
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of DUSP10.
  • Immunogen:
  • A synthetic peptide corresponding to human DUSP10.
  • Sequence:
  • CRILTPKLMGVETVV
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 52.6, 16.1
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is expected to recognize both reported human isofoms. NP_653329.1 and NP_653330.1 are varients that encode the same isoform.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:8000)
    Western blot (0.5-2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • DUSP10 polyclonal antibody (Cat # PAB6116) staining (0.5 ug/mL) of human liver lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Protein Accession#:
  • NP_009138.1;NP_653329.1;NP_653330.1
  • Gene Name:
  • DUSP10
  • Gene Alias:
  • MKP-5,MKP5
  • Gene Description:
  • dual specificity phosphatase 10
  • Gene Summary:
  • Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000035380,dual specificity phosphatase MKP-5,map kinase phosphatase 5,serine/threonine specific protein phosphatase
  • Gene Pathway
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