DUSP10 polyclonal antibody
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Western Blot (Tissue lysate)
DUSP10 polyclonal antibody (Cat # PAB6116) staining (0.5 ug/mL) of human liver lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DUSP10.
Immunogen
A synthetic peptide corresponding to human DUSP10.
Sequence
CRILTPKLMGVETVV
Host
Goat
Theoretical MW (kDa)
52.6, 16.1
Reactivity
Human
Specificity
This antibody is expected to recognize both reported human isofoms. NP_653329.1 and NP_653330.1 are varients that encode the same isoform.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
DUSP10 polyclonal antibody (Cat # PAB6116) staining (0.5 ug/mL) of human liver lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DUSP10
Entrez GeneID
11221Protein Accession#
NP_009138.1;NP_653329.1;NP_653330.1Gene Name
DUSP10
Gene Alias
MKP-5, MKP5
Gene Description
dual specificity phosphatase 10
Omim ID
608867Gene Ontology
HyperlinkGene Summary
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000035380|dual specificity phosphatase MKP-5|map kinase phosphatase 5|serine/threonine specific protein phosphatase
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Interactome
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Pathway
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Publication Reference
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Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.
Tanoue T, Moriguchi T, Nishida E.
The Journal of Biological Chemistry 1999 Jul; 274(28):19949.
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Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.
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