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Last updated: 2017/5/28
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DUSP8 polyclonal antibody

  • Catalog # : PAB6114
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of DUSP8.
  • Immunogen:
  • A synthetic peptide corresponding to human DUSP8.
  • Sequence:
  • *AGDRLPRKVMDAK-C
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 65.8
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is also expected to recognize the hypothetical human protein similar to dual specificity phosphatase 8 (XM_114902), which is virtually identical.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:4000)
    Western blot (1-3 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • DUSP8 polyclonal antibody (Cat # PAB6114) staining (2 ug/mL) of human heart lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 1850
  • Gene Name:
  • DUSP8
  • Gene Alias:
  • C11orf81,FLJ42476,FLJ42958,HB5,HVH-5,HVH8
  • Gene Description:
  • dual specificity phosphatase 8
  • Gene Summary:
  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq
  • Other Designations:
  • H1 phosphatase, vaccinia virus homolog,serine/threonine specific protein phosphatase
  • Gene Pathway
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