ELMO1 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
ELMO1 polyclonal antibody (Cat # PAB6103) staining (1 ug/mL) of Jurkat lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ELMO1.
Immunogen
A synthetic peptide corresponding to C-terminus of human ELMO1.
Sequence
PKEPSNYDFVYDCN
Host
Goat
Theoretical MW (kDa)
83.8, 28.7
Reactivity
Bovine, Human, Zebra fish
Specificity
This antibody is expected to recognize both human isoforms of this protein. NP_569709.1 and NP_0010.34548.1 represent the same isoform.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
ELMO1 polyclonal antibody (Cat # PAB6103) staining (1 ug/mL) of Jurkat lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ELMO1
Entrez GeneID
9844Protein Accession#
NP_055615.8;NP_569709.1;NP_0010.34548.1Gene Name
ELMO1
Gene Alias
CED-12, CED12, ELMO-1, KIAA0281, MGC126406
Gene Description
engulfment and cell motility 1
Omim ID
606420Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. Similarity to a C. elegans protein suggests that this protein may function in apoptosis and in cell migration. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
ced-12 homolog 1
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Interactome
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Pathway
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Disease
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Publication Reference
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A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.
Cote JF, Motoyama AB, Bush JA, Vuori K.
Nature Cell Biology 2005 Jul; 7(8):797.
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A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.
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