PTGS1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PTGS1.
Immunogen
A synthetic peptide corresponding to human PTGS1.
Sequence
C-QDDGPAVERPSTEL
Host
Goat
Theoretical MW (kDa)
68.7, 64.5
Reactivity
Human
Specificity
This antibody is expected to recognize both human isoforms of this protein according to NP_000953.2 and NP_542158.1.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (3-5 ug/mL)
Western blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
PTGS1 polyclonal antibody (Cat # PAB6095) staining (1 ug/mL) of U937 cell lysate (35 ug protein in RIPA buffer). Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
PTGS1 polyclonal antibody (Cat # PAB6095) (3.8 ug/mL) staining of paraffin embedded human heart. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTGS1
Entrez GeneID
5742Protein Accession#
NP_000953.2;NP_542158.1Gene Name
PTGS1
Gene Alias
COX1, COX3, PCOX1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
Gene Description
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Omim ID
176805Gene Ontology
HyperlinkGene Summary
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq
Other Designations
OTTHUMP00000022052|OTTHUMP00000022053|prostaglandin G/H synthase and cyclooxygenase|prostaglandin-endoperoxide synthase 1
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Interactome
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Pathway
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Disease
- Abdominal Pain
- Adenocarcinoma
- Adenoma
- Adenomatous Polyps
- Alzheimer disease
- Asthma
- Atherosclerosis
- Atrophy
- Brain Ischemia
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Publication Reference
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Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme.
Yokoyama C, Tanabe T.
Biochemical and Biophysical Research Communications 1989 Dec; 165(2):888.
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Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme.
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