PTP4A1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PTP4A1.
Immunogen
A synthetic peptide corresponding to human PTP4A1.
Sequence
KDSNGHRNNCCIQ
Host
Goat
Theoretical MW (kDa)
19.8
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
PTP4A1 polyclonal antibody (Cat # PAB6077) staining (1 ug/mL) of A-549 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTP4A1
Entrez GeneID
7803Protein Accession#
NP_0.03454.1Gene Name
PTP4A1
Gene Alias
DKFZp779M0721, HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1
Gene Description
protein tyrosine phosphatase type IVA, member 1
Omim ID
601585Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. [provided by RefSeq
Other Designations
OTTHUMP00000016675|Protein tyrosine phosphatase IVA1|protein tyrosine phosphatase type IVA protein 1
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Interactome
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Disease
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Publication Reference
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The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer.
Peng Y, Genin A, Spinner NB, Diamond RH, Taub R.
The Journal of Biological Chemistry 1998 Jul; 273(27):17286.
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The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer.
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