DUSP16 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
DUSP16 polyclonal antibody (Cat # PAB6074) staining (2.5 ug/mL) of paraffin embedded human placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DUSP16.
Immunogen
A synthetic peptide corresponding to human DUSP16.
Sequence
AHEMIGTQIVTER-C
Host
Goat
Theoretical MW (kDa)
73
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
DUSP16 polyclonal antibody (Cat # PAB6074) staining (2.5 ug/mL) of paraffin embedded human placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DUSP16
Entrez GeneID
80824Protein Accession#
NP_085143.1Gene Name
DUSP16
Gene Alias
KIAA1700, MGC129701, MGC129702, MKP-7, MKP7
Gene Description
dual specificity phosphatase 16
Omim ID
607175Gene Ontology
HyperlinkGene Summary
The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM
Other Designations
MAPK phosphatase-7
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Interactome
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Pathway
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Disease
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Publication Reference
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A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.
Tanoue T, Yamamoto T, Maeda R, Nishida E.
The Journal of Biological Chemistry 2001 Jul; 276(28):26629.
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A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.
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