MTM1 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MTM1.
Immunogen
A synthetic peptide corresponding to human MTM1.
Sequence
C-SSPSQMMPHVQTHF
Host
Goat
Theoretical MW (kDa)
69.9
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
MTM1 polyclonal antibody (Cat # PAB6061) staining (0.3 ug/mL) of HepG2 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Western Blot (Transfected lysate)
HEK293 overexpressing MTM1 and probed with MTM1 polyclonal antibody (Cat # PAB6061) (mock transfection in first lane), tested by Origene.Enzyme-linked Immunoabsorbent Assay
-
Gene Info — MTM1
Entrez GeneID
4534Protein Accession#
NP_000243.1Gene Name
MTM1
Gene Alias
CNM, MTMX, XLMTM
Gene Description
myotubularin 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq
Other Designations
myotubularin
-
Interactome
-
Disease
-
Publication Reference
-
Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders.
Jihad El Andari, Edith Renaud-Gabardos, Warut Tulalamba, Jonas Weinmann, Louise Mangin, Quang Hong Pham, Susanne Hille, Antonette Bennett, Esther Attebi, Emanuele Bourges, Christian Leborgne, Nicolas Guerchet, Julia Fakhiri, Chiara Krämer, Ellen Wiedtke, Robert McKenna, Laurence Guianvarc'h, Magali Toueille, Giuseppe Ronzitti, Matthias Hebben, Federico Mingozzi, Thierry VandenDriessche, Mavis Agbandje-McKenna, Oliver J Müller, Marinee K Chuah, Ana Buj-Bello, Dirk Grimm.
Science Advances 2022 Sep; 8(38):eabn4704.
Application:WB-Tr, Mouse, Mouse muscle.
-
Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species.
Mohammadsharif Tabebordbar, Kim A Lagerborg, Alexandra Stanton, Emily M King, Simon Ye, Liana Tellez, Allison Krunnfusz, Sahar Tavakoli, Jeffrey J Widrick, Kathleen A Messemer, Emily C Troiano, Behzad Moghadaszadeh, Bryan L Peacker, Krystynne A Leacock, Naftali Horwitz, Alan H Beggs, Amy J Wagers, Pardis C Sabeti.
Cell 2021 Sep; 184(19):4919.
Application:WB-Ti, WB-Tr, Mouse, Mouse muscles.
-
A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast.
Laporte J, Hu LJ, Kretz C, Mandel JL, Kioschis P, Coy JF, Klauck SM, Poustka A, Dahl N.
Nature Genetics 1996 Jun; 13(2):175.
-
Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com