TIRAP polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TIRAP.
Immunogen
A synthetic peptide corresponding to human TIRAP.
Sequence
C-EGEGERDSATVSDL
Host
Goat
Theoretical MW (kDa)
25.3
Reactivity
Human
Specificity
This antibody is expected to recognize isoform b only (as represented by NP_683708.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
TIRAP polyclonal antibody (Cat # PAB6059) staining (1 ug/mL) of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TIRAP
Entrez GeneID
114609Protein Accession#
NP_683708.1Gene Name
TIRAP
Gene Alias
FLJ42305, Mal, wyatt
Gene Description
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Gene Ontology
HyperlinkGene Summary
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq
Other Designations
MyD88 adapter-like protein|OTTHUMP00000179130|OTTHUMP00000179132|TIR domain-containing adapter protein|TIR domain-containing adaptor protein|Toll-interleukin 1 receptor (TIR) domain-containing adapter protein|Toll-interleukin 1 receptor (TIR) domain-conta
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Interactome
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Pathway
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Disease
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Publication Reference
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Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.
Andreakos E, Sacre SM, Smith C, Lundberg A, Kiriakidis S, Stonehouse T, Monaco C, Feldmann M, Foxwell BM.
Blood 2004 Mar; 103(6):2229.
Application:WB, Human, Human macrophages.
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Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.
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