BAG2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
BAG2 polyclonal antibody (Cat # PAB6054) staining (0.3 ug/mL) of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of BAG2.
Immunogen
A synthetic peptide corresponding to human BAG2.
Sequence
CSKTLQQNAESRFN
Host
Goat
Theoretical MW (kDa)
23.7
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
BAG2 polyclonal antibody (Cat # PAB6054) staining (0.3 ug/mL) of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — BAG2
Entrez GeneID
9532Protein Accession#
NP_004273.1Gene Name
BAG2
Gene Alias
BAG-2, KIAA0576, MGC149462, dJ417I1.2
Gene Description
BCL2-associated athanogene 2
Omim ID
603882Gene Ontology
HyperlinkGene Summary
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq
Other Designations
BAG-family molecular chaperone regulator-2|OTTHUMP00000016668|dJ417I1.2 (BAG-family molecular chaperone regulator 2)
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Interactome
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Publication Reference
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Regulation of the cytoplasmic quality control protein degradation pathway by BAG2.
Dai Q, Qian SB, Li HH, McDonough H, Borchers C, Huang D, Takayama S, Younger JM, Ren HY, Cyr DM, Patterson C.
The Journal of Biological Chemistry 2005 Sep; 280(46):38673.
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Regulation of the cytoplasmic quality control protein degradation pathway by BAG2.
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