BIRC7 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
BIRC7 polyclonal antibody (Cat # PAB6033) staining (0.3 ug/mL) of MOLT 4 lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of BIRC7.
Immunogen
A synthetic peptide corresponding to human BIRC7.
Sequence
C-RAPVRSRVRT
Host
Goat
Theoretical MW (kDa)
32.8, 30.9
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (as represented by NP_647478.1 and NP_071444.1)
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
Western Blot (0.1-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
BIRC7 polyclonal antibody (Cat # PAB6033) staining (0.3 ug/mL) of MOLT 4 lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — BIRC7
Entrez GeneID
79444Protein Accession#
NP_647478.1;NP_071444.1Gene Name
BIRC7
Gene Alias
KIAP, LIVIN, ML-IAP, MLIAP, RNF50
Gene Description
baculoviral IAP repeat-containing 7
Omim ID
605737Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. [provided by RefSeq
Other Designations
OTTHUMP00000031536|OTTHUMP00000031537|baculoviral IAP repeat-containing protein 7|kidney inhibitor of apoptosis protein|livin inhibitor of apoptosis|livin inhibitor-of-apoptosis|melanoma inhibitor of apoptosis protein
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Interactome
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Publication Reference
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Telomere-based DNA damage responses: a new approach to melanoma.
Puri N, Eller MS, Byers HR, Dykstra S, Kubera J, Gilchrest BA.
FASEB Journal 2004 Sep; 18(12):1373.
Application：WB, Human, MM-AN cells.
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Telomere-based DNA damage responses: a new approach to melanoma.
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