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Last updated: 2016/12/4
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STAT3 polyclonal antibody

  • Catalog # : PAB6030
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of STAT3.
  • Immunogen:
  • A synthetic peptide corresponding to C-terminus of human STAT3.
  • Sequence:
  • DMELTSECATSPM
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 88.0, 88.1
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • This antibody is expected to recognize isoforms 1 and 2 (as represented by NP_644805.1 and NP_003141.2 respectively).
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:4000)
    Western Blot (0.5 ug/mL)
    Immunohistochemistry (4-8 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • 1.
  • Stat3 as an oncogene.
    Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Darnell JE Jr.Cell. 1999 Aug 6;98(3):295-303.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • STAT3 polyclonal antibody (Cat # PAB6030) (4 ug/mL) staining of paraffin embedded mouse thymus. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
  • Immunofluorescence
  • ELISA
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunofluorescence
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 6774
  • Protein Accession#:
  • NP_003141.2;NP_644805.1
  • Gene Name:
  • STAT3
  • Gene Alias:
  • APRF,FLJ20882,HIES,MGC16063
  • Gene Description:
  • signal transducer and activator of transcription 3 (acute-phase response factor)
  • Gene Summary:
  • The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
  • Other Designations:
  • DNA-binding protein APRF,acute-phase response factor,signal transducer and activator of transcription 3
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