BCAR3 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of BCAR3.
Immunogen
A synthetic peptide corresponding to human BCAR3.
Sequence
C-RKLEPPPVKQAEL
Host
Goat
Theoretical MW (kDa)
92.5
Reactivity
Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
BCAR3 polyclonal antibody (Cat # PAB6029, 0.5 ug/mL) staining of mouse embryonic kidney epithelial cells lysate (15 ug protein in RIPA buffer) . Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — BCAR3
Entrez GeneID
8412Protein Accession#
NP_003558Gene Name
BCAR3
Gene Alias
KIAA0554, NSP2, SH2D3B
Gene Description
breast cancer anti-estrogen resistance 3
Omim ID
604704Gene Ontology
HyperlinkGene Summary
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. [provided by RefSeq
Other Designations
OTTHUMP00000011959|OTTHUMP00000011960|OTTHUMP00000011961|breast cancer antiestrogen resistance 3|dJ1033H22.2 (breast cancer anti-estrogen resistance 3)
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Interactome
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Disease
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Publication Reference
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Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells.
van Agthoven T, van Agthoven TL, Dekker A, van der Spek PJ, Vreede L, Dorssers LC.
The EMBO Journal 1998 May; 17(10):2799.
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Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells.
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