ORC3L polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ORC3L.
Immunogen
A synthetic peptide corresponding to human ORC3L.
Sequence
QKTDHVARLTWGGC
Host
Goat
Theoretical MW (kDa)
82.3, 82.3
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_862820.1 and NP_0.36513.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
ORC3L polyclonal antibody (Cat # PAB6027) staining (2 ug/mL) of HeLa lysate (RIPA buffer, 1.4E5 cells per lane). Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ORC3L
Entrez GeneID
23595Protein Accession#
NP_862820.1;NP_0.36513.2Gene Name
ORC3L
Gene Alias
LAT, LATHEO, ORC3
Gene Description
origin recognition complex, subunit 3-like (yeast)
Omim ID
604972Gene Ontology
HyperlinkGene Summary
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000016835|OTTHUMP00000040611|homolog of latheo, Drosophila|origin recognition complex, subunit 3
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Interactome
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Pathway
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Disease
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Publication Reference
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latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant.
Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A.
Neuron 1999 May; 23(1):45.
Application:IHC-P, IP, WB-Ce, Human, Firefly, Firefly brains, HEK 293 cells.
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latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant.
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