AKAP12 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of AKAP12.
Immunogen
A synthetic peptide corresponding to C terminus of human AKAP12.
Sequence
KQERESAKSELTES
Host
Goat
Theoretical MW (kDa)
181, 191
Reactivity
Human
Specificity
This anrtibody is expected to recognize both reported isoforms.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.02-0.1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — AKAP12
Entrez GeneID
9590Protein Accession#
NP_005091.2;NP_653080.1Gene Name
AKAP12
Gene Alias
AKAP250, DKFZp686M0430, DKFZp686O0331, FLJ20945, FLJ97621
Gene Description
A kinase (PRKA) anchor protein 12
Omim ID
604698Gene Ontology
HyperlinkGene Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
A kinase (PRKA) anchor protein (gravin) 12|A-kinase anchor protein, 250kDa|OTTHUMP00000017426|kinase scaffold protein gravin|myasthenia gravis autoantigen gravin
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Interactome
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Disease
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