SORL1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
SORL1 polyclonal antibody (Cat # PAB6016, 0.3 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer) . Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SORL1.
Immunogen
A synthetic peptide corresponding to C-terminus of human SORL1.
Sequence
C-TGFSDDVPMVIA
Host
Goat
Theoretical MW (kDa)
248
Reactivity
Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
SORL1 polyclonal antibody (Cat # PAB6016, 0.3 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer) . Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SORL1
Entrez GeneID
6653Protein Accession#
NP_003096.1Gene Name
SORL1
Gene Alias
C11orf32, FLJ21930, FLJ39258, LR11, LRP9, SORLA, SorLA-1, gp250
Gene Description
sortilin-related receptor, L(DLR class) A repeats-containing
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the families of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins, of low density lipoprotein receptor (LDLR) proteins, and of fibronectin type III repeats proteins. In addition to VPS10, LDLR and fibronectin type 3 domains, this protein also includes an epidermal growth factor precursor-like module, a single transmembrane segment and a cytoplasmic tail with features similar to endocytosis- and sorting-competent receptors. Members of the VPS10 domain-containing receptor family are large with many exons but the CDS lengths are usually less than 3700 nt; this gene is an exception to the pattern with a CDS length greater than 6600 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. The encoded protein is mainly intracellular and localizes in the paranuclear compartment. It is synthesized as a preproprotein, and when the propeptide is still attached, no binding occurs to the VPS10 domain. This gene is strongly expressed in the central nervous system. [provided by RefSeq
Other Designations
mosaic protein LR11|sortilin-related receptor containing LDLR class A repeats
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Interactome
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Disease
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Publication Reference
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Activation and functional characterization of the mosaic receptor SorLA/LR11.
Jacobsen L, Madsen P, Jacobsen C, Nielsen MS, Gliemann J, Petersen CM.
The Journal of Biological Chemistry 2001 Jun; 276(25):22788.
Application：IF, WB-Tr, Mouse, CHO cells.
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Activation and functional characterization of the mosaic receptor SorLA/LR11.
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