SEC61A1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
SEC61A1 polyclonal antibody (Cat # PAB6000) (0.3 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SEC61A1.
Immunogen
A synthetic peptide corresponding to C-terminus of human SEC61A1.
Sequence
C-KEQSEVGSMGALLF
Host
Goat
Theoretical MW (kDa)
52.3
Reactivity
Human, Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Western blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
SEC61A1 polyclonal antibody (Cat # PAB6000) (0.3 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SEC61A1
Entrez GeneID
29927Protein Accession#
NP_037468.1Gene Name
SEC61A1
Gene Alias
HSEC61, SEC61, SEC61A
Gene Description
Sec61 alpha 1 subunit (S. cerevisiae)
Omim ID
609213Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq
Other Designations
Sec61 alpha 1 subunit|Sec61 alpha-1|protein transport protein SEC61 alpha subunit|sec61 homolog
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Interactome
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Pathway
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Publication Reference
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A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation.
Gorlich D, Prehn S, Hartmann E, Kalies KU, Rapoport TA.
Cell 1992 Oct; 71(3):489.
Application：WB, Dog, MDCK (NBL-2) cells.
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A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation.
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