TP73 (phospho Y99) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of TP73.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y99 of human TP73.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from K-562 cells using TP73 (phospho Y99) polyclonal antibody (Cat # PAB5789). -
Gene Info — TP73
Entrez GeneID
7161Gene Name
TP73
Gene Alias
P73
Gene Description
tumor protein p73
Omim ID
601990Gene Ontology
HyperlinkGene Summary
This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000000662|p53-like transcription factor|p53-related protein
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Interactome
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Pathway
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Disease
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Publication Reference
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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.
Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, Lu H, Kharbanda S, Weichselbaum R, Kufe D.
Nature 1999 Jun; 399(6738):814.
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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.
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