ITGB3 (phospho Y773) polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of ITGB3.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y773 of human ITGB3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extract from HL-60 using ITGB3 (phospho Y773) polyclonal antibody (Cat # PAB5733).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ITGB3 (phospho Y773) polyclonal antibody (Cat # PAB5733). -
Gene Info — ITGB3
Entrez GeneID
3690Gene Name
ITGB3
Gene Alias
CD61, GP3A, GPIIIa
Gene Description
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Omim ID
173470Gene Ontology
HyperlinkGene Summary
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq
Other Designations
integrin beta chain, beta 3|platelet glycoprotein IIIa
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Interactome
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Pathway
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Disease
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Publication Reference
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Beta 3 integrin phosphorylation is essential for Arp3 organization into leukocyte alpha V beta 3-vitronectin adhesion contacts.
Chandhoke SK, Williams M, Schaefer E, Zorn L, Blystone SD.
Journal of Cell Science 2004 Mar; 117(Pt 8):1431.
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Phosphorylation of beta3 integrin controls ligand binding strength.
Datta A, Huber F, Boettiger D.
The Journal of Biological Chemistry 2001 Nov; 277(6):3943.
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Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation.
Law DA, Nannizzi-Alaimo L, Phillips DR.
The Journal of Biological Chemistry 1996 May; 271(18):10811.
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Beta 3 integrin phosphorylation is essential for Arp3 organization into leukocyte alpha V beta 3-vitronectin adhesion contacts.
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