MAP2K4 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extract from NIH/3T3 cells using MAP2K4 polyclonal antibody (Cat # PAB5570) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAP2K4.
Immunogen
A synthetic peptide corresponding to residues surrounding S80 of human MAP2K4.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extract from NIH/3T3 cells using MAP2K4 polyclonal antibody (Cat # PAB5570) . -
Gene Info — MAP2K4
Entrez GeneID
6416Gene Name
MAP2K4
Gene Alias
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SEK1, SERK1
Gene Description
mitogen-activated protein kinase kinase 4
Omim ID
601335Gene Ontology
HyperlinkGene Summary
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq
Other Designations
JNK activating kinase 1|JNK-activated kinase 1|MAP kinase kinase 4|MAPK/ERK kinase 4|SAPK/ERK kinase 1|c-Jun N-terminal kinase kinase 1|dual specificity mitogen-activated protein kinase kinase 4
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Interactome
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Pathway
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Disease
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Publication Reference
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Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation.
Park HS, Kim MS, Huh SH, Park J, Chung J, Kang SS, Choi EJ.
The Journal of Biological Chemistry 2001 Nov; 277(4):2573.
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Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation.
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