DOK1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from Jurkat cells , using DOK1 polyclonal antibody (Cat # PAB5500) .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using DOK1 polyclonal antibody (Cat # PAB5500) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DOK1.
Immunogen
A synthetic peptide corresponding to residues surrounding Y362 of human DOK1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from Jurkat cells , using DOK1 polyclonal antibody (Cat # PAB5500) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using DOK1 polyclonal antibody (Cat # PAB5500) . -
Gene Info — DOK1
Entrez GeneID
1796Gene Name
DOK1
Gene Alias
MGC117395, MGC138860, P62DOK
Gene Description
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Omim ID
602919Gene Ontology
HyperlinkGene Summary
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. [provided by RefSeq
Other Designations
Downstream of tyrosine kinase 1|docking protein 1|docking protein 1 (downstream of tyrosine kinase 1)|docking protein 1, 62kD (downstream of tyrosine kinase 1)
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Interactome
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Disease
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Publication Reference
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The pre-B cell receptor signaling for apoptosis is negatively regulated by Fc gamma RIIB.
Kato I, Takai T, Kudo A.
Journal of Immunology 2002 Jan; 168(2):629.
Application：IP, WB, Mouse, Mouse B cells.
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Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling.
Songyang Z, Yamanashi Y, Liu D, Baltimore D.
The Journal of Biological Chemistry 2000 Jan; 276(4):2459.
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Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling.
Nemorin JG, Duplay P.
The Journal of Biological Chemistry 2000 May; 275(19):14590.
Application：IP, WB-Ce, WB-Tr, Human, Jurkat cells.
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The pre-B cell receptor signaling for apoptosis is negatively regulated by Fc gamma RIIB.
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