GSK3A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GSK3A.
Immunogen
A synthetic peptide corresponding to residues surrounding S21 of human GSK3A.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from ovary cancer cells , using GSK3A polyclonal antibody (Cat # PAB5378) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GSK3A polyclonal antibody (Cat # PAB5378) . -
Gene Info — GSK3A
Entrez GeneID
2931Gene Name
GSK3A
Gene Alias
DKFZp686D0638
Gene Description
glycogen synthase kinase 3 alpha
Omim ID
606784Gene Ontology
HyperlinkGene Summary
Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?
Barry FA, Graham GJ, Fry MJ, Gibbins JM.
FEBS Letters 2003 Oct; 553(1-2):173.
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Glycogen synthase kinase-3 regulates formation of long lamellipodia in human keratinocytes.
Koivisto L, Alavian K, Hakkinen L, Pelech S, McCulloch CA, Larjava H.
Journal of Cell Science 2003 Sep; 116(Pt 18):3749.
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Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin.
Srivastava AK, Pandey SK.
Molecular and Cellular Biochemistry 1998 May; 182(1-2):135.
Application:WB-Ce, WB-Tr, Human, Mammalian cells.
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Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?
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