FOXO1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FOXO1.
Immunogen
A synthetic peptide corresponding to residues surrounding S319 of human FOXO1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extract from 293 and Hela using FOXO1 polyclonal antibody (Cat # PAB5363) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FOXO1 polyclonal antibody (Cat # PAB5363) . -
Gene Info — FOXO1
Entrez GeneID
2308Gene Name
FOXO1
Gene Alias
FKH1, FKHR, FOXO1A
Gene Description
forkhead box O1
Gene Ontology
HyperlinkGene Summary
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq
Other Designations
OTTHUMP00000018301|forkhead box O1A (rhabdomyosarcoma)|forkhead homolog in rhabdomyosarcoma|forkhead, Drosophila, homolog of, in rhabdomyosarcoma
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Interactome
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Pathway
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Disease
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Publication Reference
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Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.
Zhao X, Gan L, Pan H, Kan D, Majeski M, Adam SA, Unterman TG.
The Biochemical Journal 2004 Mar; 378(Pt 3):839.
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Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.
Rena G, Woods YL, Prescott AR, Peggie M, Unterman TG, Williams MR, Cohen P.
The EMBO Journal 2002 May; 21(9):2263.
Application:WB-Tr, Human, HEK 293 cells.
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Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.
Rena G, Prescott AR, Guo S, Cohen P, Unterman TG.
The Biochemical Journal 2001 Mar; 354(Pt 3):605.
Application:WB-Tr, Human, HEK 293 cells.
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Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.
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