ELK1 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ELK1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to residues surrounding S383 of human ELK1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Transfected lysate)
Western blot analysis of ELK1 (arrow) using rabbit ELK1 polyclonal antibody (Cat # PAB4937). 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ELK1 gene (Lane 2) (Origene Technologies).Enzyme-linked Immunoabsorbent Assay
-
Gene Info — ELK1
Entrez GeneID
2002Protein Accession#
NP_005220;P19419Gene Name
ELK1
Gene Alias
-
Gene Description
ELK1, member of ETS oncogene family
Omim ID
311040Gene Ontology
HyperlinkGene Summary
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
ELK1 protein|OTTHUMP00000023224|OTTHUMP00000023225
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1.
Salinas S, Briancon-Marjollet A, Bossis G, Lopez MA, Piechaczyk M, Jariel-Encontre I, Debant A, Hipskind RA.
Journal of Cellular Biology 2004 Jun; 165(6):767.
-
Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity.
Yang SH, Jaffray E, Hay RT, Sharrocks AD.
Molecular Cell 2003 Jul; 12(1):63.
-
Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF.
Bebien M, Salinas S, Becamel C, Richard V, Linares L, Hipskind RA.
Oncogene 2003 Mar; 22(12):1836.
-
SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com