Immunohistochemistry on formalin-fixed and paraffin-embedded human prostate tissue. (Top) Coloration with the HSD17B10 polyclonal antibody (Cat # PAB4902) at a 1 : 20 concentration. (Bottom) Antibody adsorbed to the antigen (peptide), negative control. Disappearance of cytoplasmic staining indicating the antibody is specific. Data and protocol courtesy of Marie-Helene Levesque, Centre de Recherche du CHUL, Canada.
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq