TOB2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysate (35 ug/lane) with TOB2 polyclonal antibody (Cat # PAB4858).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with TOB2 polyclonal antibody (Cat # PAB4858) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TOB2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human TOB2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysate (35 ug/lane) with TOB2 polyclonal antibody (Cat # PAB4858).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with TOB2 polyclonal antibody (Cat # PAB4858) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TOB2
Entrez GeneID
10766Protein Accession#
NP_057356;Q14106Gene Name
TOB2
Gene Alias
TOB4, TOBL, TROB2
Gene Description
transducer of ERBB2, 2
Omim ID
607396Gene Ontology
HyperlinkGene Summary
TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM
Other Designations
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Interactome
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Publication Reference
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Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system.
Sasajima H, Nakagawa K, Yokosawa H.
European Journal of Biochemistry 2002 Jul; 269(14):3596.
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Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.
Y Yoshida, E Hosoda, T Nakamura, T Yamamoto.
Japanese Journal of Cancer Research 2001 Jun; 92(6):592.
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A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob.
Suzuki T, Matsuda S, Tsuzuku JK, Yoshida Y, Yamamoto T.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms 2001 Feb; 6(2):131.
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Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system.
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