Products

Western Blot (Cell lysate)

Western blot analysis of WISP3 polyclonal antibody (Cat # PAB4837) in HepG2 cell lysate (35 ug/lane). WISP3 (arrow) was detected using the purified polyclonal antibody.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with WISP3 polyclonal antibody (Cat # PAB4837) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

8838

Protein Accession#

WSP3_HUMAN

Gene Name

WISP3

Gene Alias

CCN6, LIBC, MGC125987, MGC125988, MGC125989, PPAC, PPD

Gene Description

WNT1 inducible signaling pathway protein 3

Omim ID

208230 603400

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

OTTHUMP00000017037|OTTHUMP00000017038|OTTHUMP00000040421