TAP1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TAP1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human TAP1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Jurkat cell lysate (35 ug/lane) with TAP1 polyclonal antibody (Cat # PAB4832).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with TAP1 polyclonal antibody (Cat # PAB4832) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — TAP1
Entrez GeneID
6890Protein Accession#
A41538;Q96CP4Gene Name
TAP1
Gene Alias
ABC17, ABCB2, APT1, D6S114E, FLJ26666, FLJ41500, PSF1, RING4, TAP1*0102N, TAP1N
Gene Description
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq
Other Designations
ABC transporter, MHC 1|ATP-binding cassette transporter|ATP-binding cassette, sub-family B (MDR/TAP), member 2|ATP-binding cassette, sub-family B, member 2|OTTHUMP00000029077|antigen peptide transporter 1|peptide supply factor 1|transporter 1, ATP-binding
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Interactome
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Pathway
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Disease
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Publication Reference
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Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases.
Lajoie J, Zijenah LS, Faucher MC, Ward BJ, Roger M.
Human Immunology 2003 Aug; 64(8):823.
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Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing.
Gaudet R, Wiley DC.
The EMBO Journal 2001 Sep; 20(17):4964.
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TAPI polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies.
Tang J, Freedman DO, Allen S, Karita E, Musonda R, Braga C, Margolick J, Kaslow RA.
Human Immunology 2001 Mar; 62(3):256.
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Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases.
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