Products

Western Blot (Tissue lysate)

The CD82 polyclonal antibody (Cat # PAB4830) is used in Western blot to detect CD82 in mouse liver tissue lysate.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with CD82 polyclonal antibody (Cat # PAB4830) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.

Enzyme-linked Immunoabsorbent Assay

Flow Cytometry

Flow cytometric analysis of HepG2 cells using CD82 polyclonal antibody (Cat # PAB4830)(bottom histogram) compared to a negative control cell (top histogram).
FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Entrez GeneID

3732

Protein Accession#

NP_002222

Gene Name

CD82

Gene Alias

4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27

Gene Description

CD82 molecule

Omim ID

176807 600623

Gene Ontology

Hyperlink

Gene Summary

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq

Other Designations

C33 antigen|CD82 antigen|R2 leukocyte antigen|inducible membrane protein R2|kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))|suppression of tumorigenicity 6|suppress