ST5 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ST5.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ST5.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of U251 cell lysate (35 ug/lane) with ST5 polyclonal antibody (Cat # PAB4829).Enzyme-linked Immunoabsorbent Assay
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Gene Info — ST5
Entrez GeneID
6764Protein Accession#
NP_005409Gene Name
ST5
Gene Alias
DENND2B, HTS1, MGC33090, p126
Gene Description
suppression of tumorigenicity 5
Omim ID
140750Gene Ontology
HyperlinkGene Summary
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq
Other Designations
DENN/MADD domain containing 2B
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Interactome
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Disease
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Publication Reference
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Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells.
Majidi M, Gutkind JS, Lichy JH.
The Journal of Biological Chemistry 2000 Mar; 275(9):6560.
Application:WB-Tr, Mouse, NIH/3T3 cells.
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Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology.
Hubbs AE, Majidi M, Lichy JH.
Oncogene 1999 Apr; 18(15):2519.
Application:WB-Re, WB-Tr, Mouse, NIH/3T3 cells, Recombinant protein.
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Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5.
Majidi M, Hubbs AE, Lichy JH.
The Journal of Biological Chemistry 1998 Jun; 273(26):16608.
Application:WB, Human, COS-7 cells.
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Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells.
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