ST14 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ST14.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ST14.
Host
Rabbit
Reactivity
Mouse
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse liver tissue lysate (35 ug/lane) with ST14 polyclonal antibody (Cat # PAB4828).Enzyme-linked Immunoabsorbent Assay
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Gene Info — ST14
Entrez GeneID
6768Protein Accession#
NP_068813Gene Name
ST14
Gene Alias
HAI, MT-SP1, MTSP-1, MTSP1, PRSS14, SNC19, TADG-15
Gene Description
suppression of tumorigenicity 14 (colon carcinoma)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq
Other Designations
epithin|matriptase|membrane-type serine protease|serine protease TADG-15|suppression of tumorigenicity 14|suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)|tumor associated differentially expressed gene 15 protein
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Interactome
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Disease
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Publication Reference
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The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma.
Santin AD, Cane' S, Bellone S, Bignotti E, Palmieri M, De Las Casas LE, Anfossi S, Roman JJ, O'Brien T, Pecorelli S.
Cancer 2003 Nov; 98(9):1898.
Application:IHC-P, Human, Human cervical carcinoma.
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The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor.
Oberst MD, Williams CA, Dickson RB, Johnson MD, Lin CY.
The Journal of Biological Chemistry 2003 Jul; 278(29):26773.
Application:WB, Human, BT549 cells.
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Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching.
Ihara S, Miyoshi E, Ko JH, Murata K, Nakahara S, Honke K, Dickson RB, Lin CY, Taniguchi N.
The Journal of Biological Chemistry 2002 May; 277(19):16960.
Application:Flow Cyt, WB, Human, MKN45 cells.
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The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma.
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