OAS1 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of OAS1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human OAS1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
The OAS1 polyclonal antibody (Cat # PAB4810) is used in Western blot to detect OAS1 in mouse liver lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 polyclonal antibody (Cat # PAB4810) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.Enzyme-linked Immunoabsorbent Assay
-
Gene Info — OAS1
Entrez GeneID
4938Protein Accession#
NP_002525;P00973Gene Name
OAS1
Gene Alias
IFI-4, OIAS, OIASI
Gene Description
2',5'-oligoadenylate synthetase 1, 40/46kDa
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq
Other Designations
(2'-5') oligoadenylate synthetase 1|2',5'-oligo A synthetase 1|2',5'-oligoadenylate synthetase 1|2',5'-oligoadenylate synthetase 1 (40-46 kD)|2'-5' oligoadenylate synthetase 1 p48 isoform|2'-5' oligoadenylate synthetase 1 p52 isoform|2'-5'-oligoisoadenyla
-
Interactome
-
Disease
-
Publication Reference
-
Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression.
Wang H, Ghosh A, Baigude H, Yang CS, Qiu L, Xia X, Zhou H, Rana TM, Xu Z.
The Journal of Biological Chemistry 2008 Mar; 283(23):15845.
-
A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
Han JQ, Townsend HL, Jha BK, Paranjape JM, Silverman RH, Barton DJ.
Journal of Virology 2007 Mar; 81(11):5561.
-
IFI16 in human prostate cancer.
Alimirah F, Chen J, Davis FJ, Choubey D.
Molecular Cancer Research 2007 Mar; 5(3):251.
-
Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com