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Last updated: 2016/10/23
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NRG1 polyclonal antibody

  • Catalog # : PAB4805
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of NRG1.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to internal region of human NRG1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Recommend Usage:
  • Flow cytometry (1:10-50)
    Immunohistochemistry (1:50-100)
    Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of NRG1 polyclonal antibody (Cat # PAB4805) in SK-BR-3 cell lysate (35 ug/lane). NRG1 (arrow) was detected using the purified polyclonal antibody.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Formalin-fixed and paraffin-embedded human cancer tissue reacted with NRG1 polyclonal antibody (Cat # PAB4805) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of NCI-H460 cells using NRG1 polyclonal antibody (Cat # PAB4805) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 3084
  • Gene Name:
  • NRG1
  • Gene Alias:
  • Gene Description:
  • neuregulin 1
  • Gene Summary:
  • The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq
  • Other Designations:
  • glial growth factor,heregulin, alpha (45kD, ERBB2 p185-activator),neu differentiation factor,neuregulin 1 isoform HRG-gamma,sensory and motor neuron derived factor
  • Gene Pathway
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