NRG1 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NRG1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human NRG1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Saturated Ammonium Sulfate precipitation
Recommend Usage
Flow cytometry (1:10-50)
Immunohistochemistry (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with NRG1 polyclonal antibody (Cat # PAB4805) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.Flow Cytometry
Flow cytometric analysis of NCI-H460 cells using NRG1 polyclonal antibody (Cat # PAB4805) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. -
Gene Info — NRG1
Entrez GeneID
3084Protein Accession#
Q02297Gene Name
NRG1
Gene Alias
ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, NDF, SMDF
Gene Description
neuregulin 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq
Other Designations
glial growth factor|heregulin, alpha (45kD, ERBB2 p185-activator)|neu differentiation factor|neuregulin 1 isoform HRG-gamma|sensory and motor neuron derived factor
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Targeting and suppression of HER3-positive breast cancer by T lymphocytes expressing a heregulin chimeric antigen receptor.
Zuo BL, Yan B, Zheng GX, Xi WJ, Zhang X, Yang AG, Jia LT.
Cancer Immunology, Immunotherapy : CII 2018 Mar; 67(3):393.
Application:Flow Cyt, Human, HEK 293T cells.
-
The heregulin/human epidermal growth factor receptor as a new growth factor system in melanoma with multiple ways of deregulation.
Stove C, Stove V, Derycke L, Van Marck V, Mareel M, Bracke M.
The Journal of Investigative Dermatology 2003 Oct; 121(4):802.
Application:WB, Human, MCF-7 cells.
-
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.
Adelaide J, Huang HE, Murati A, Alsop AE, Orsetti B, Mozziconacci MJ, Popovici C, Ginestier C, Letessier A, Basset C, Courtay-Cahen C, Jacquemier J, Theillet C, Birnbaum D, Edwards PA, Chaffanet M.
Genes, Chromosomes & Cancer 2003 Aug; 37(4):333.
-
Neuregulin-1 enhances motility and migration of human astrocytic glioma cells.
Ritch PA, Carroll SL, Sontheimer H.
The Journal of Biological Chemistry 2003 Jun; 278(23):20971.
-
Targeting and suppression of HER3-positive breast cancer by T lymphocytes expressing a heregulin chimeric antigen receptor.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com