The MVP polyclonal antibody (Cat # PAB4800) is used in Western blot to detect MVP in A-375 cell lysate.
Western Blot (Transfected lysate)
Western blot analysis of MVP (arrow) using rabbit MVP polyclonal antibody (Cat # PAB4800). 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MVP gene (Lane 2) (Origene Technologies).
Formalin-fixed and paraffin-embedded human lung carcinomareacted with MVP polyclonal antibody (Cat # PAB4800), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Flow cytometric analysis of NCI-H292 cells using MVP polyclonal antibody (Cat # PAB4800)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. [provided by RefSeq