MMP7 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MMP7.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human MMP7.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
The MMP7 polyclonal antibody (Cat # PAB4796) is used in Western blot to detect MMP7 in 293 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with MMP7 polyclonal antibody (Cat # PAB4796) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.Enzyme-linked Immunoabsorbent Assay
-
Gene Info — MMP7
Entrez GeneID
4316Protein Accession#
MM7_HUMANGene Name
MMP7
Gene Alias
MMP-7, MPSL1, PUMP-1
Gene Description
matrix metallopeptidase 7 (matrilysin, uterine)
Omim ID
178990Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
matrin|matrix metalloproteinase 7|matrix metalloproteinase 7 (matrilysin, uterine)|uterine matrilysin
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Matrilysin-dependent elastolysis by human macrophages.
Filippov S, Caras I, Murray R, Matrisian LM, Chapman HA Jr, Shapiro S, Weiss SJ.
The Journal of Experimental Medicine 2003 Sep; 198(6):925.
Application:WB, Human, Mouse, Human monocyte-derived macrophages, Mouse macrophages.
-
Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion.
Rivat C, Le Floch N, Sabbah M, Teyrol I, Redeuilh G, Bruyneel E, Mareel M, Matrisian LM, Crawford HC, Gespach C, Attoub S.
FASEB Journal 2003 Sep; 17(12):1721.
Application:ELISA, Human, HT-29 cells.
-
Hypochlorous acid generated by myeloperoxidase modifies adjacent tryptophan and glycine residues in the catalytic domain of matrix metalloproteinase-7 (matrilysin): an oxidative mechanism for restraining proteolytic activity during inflammation.
Fu X, Kassim SY, Parks WC, Heinecke JW.
The Journal of Biological Chemistry 2003 Aug; 278(31):28403.
-
Matrilysin-dependent elastolysis by human macrophages.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com