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Western Blot (Cell lysate)

Western blot analysis of MMP20 polyclonal antibody (Cat # PAB4787) in HepG2 cell lysate (35 ug/lane). MMP20 (arrow) was detected using the purified polyclonal antibody.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with MMP20 polyclonal antibody (Cat # PAB4787) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

9313

Protein Accession#

MM20_HUMAN

Gene Name

MMP20

Gene Alias

MMP-20

Gene Description

matrix metallopeptidase 20

Omim ID

204700 604629

Gene Ontology

Hyperlink

Gene Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and so the protein is thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes that localizes to chromosome 11q22.3. [provided by RefSeq

Other Designations

enamel metalloproteinase|enamelysin|matrix metalloproteinase 20|matrix metalloproteinase 20 (enamelysin)