MMP17 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of MMP17 polyclonal antibody (Cat # PAB4785) in NCI-H460 cell lysate (35 ug/lane). MMP17 (arrow) was detected using the purified polyclonal antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with MMP17 polyclonal antibody (Cat # PAB4785) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MMP17.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human MMP17.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-200)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MMP17 polyclonal antibody (Cat # PAB4785) in NCI-H460 cell lysate (35 ug/lane). MMP17 (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with MMP17 polyclonal antibody (Cat # PAB4785) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP17
Entrez GeneID
4326Protein Accession#
MM17_HUMANGene Name
MMP17
Gene Alias
MT4-MMP
Gene Description
matrix metallopeptidase 17 (membrane-inserted)
Omim ID
602285Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq
Other Designations
matrix metalloproteinase 17|matrix metalloproteinase 17 (membrane-inserted)|membrane-type matrix metalloproteinase 4|membrane-type-4 matrix metalloproteinase
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Interactome
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Disease
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Publication Reference
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MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis.
Clemente C, Rius C, Alonso-Herranz L, Martín-Alonso M, Pollán Á, Camafeita E, Martínez F, Mota RA, Núñez V, Rodríguez C, Seiki M, Martínez-González J, Andrés V, Ricote M, Arroyo AG.
Nature Communications 2018 Mar; 9(1):910.
Application：IF, IHC-Fr, IHC-P, Mouse, Aortas, Hearts.
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mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.
Jung M, Romer A, Keyszer G, Lein M, Kristiansen G, Schnorr D, Loening SA, Jung K.
Prostate 2003 May; 55(2):89.
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Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase.
Itoh Y, Kajita M, Kinoh H, Mori H, Okada A, Seiki M.
The Journal of Biological Chemistry 1999 Nov; 274(48):34260.
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Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain.
Wang Y, Johnson AR, Ye QZ, Dyer RD.
The Journal of Biological Chemistry 1999 Nov; 274(46):33043.
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MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis.
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