MMP16 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MMP16.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MMP16.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MDA-MB-435 cell lysate (35 ug/lane) with MMP16 polyclonal antibody (Cat # PAB4784).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with MMP16 polyclonal antibody (Cat # PAB4784) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP16
Entrez GeneID
4325Protein Accession#
MM16_HUMANGene Name
MMP16
Gene Alias
C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP
Gene Description
matrix metallopeptidase 16 (membrane-inserted)
Omim ID
602262Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq
Other Designations
matrix metalloproteinase 16|matrix metalloproteinase 16 (membrane-inserted)|membrane-type matrix metalloproteinase 3|membrane-type-3 matrix metalloproteinase
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Disease
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Publication Reference
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mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.
Jung M, Romer A, Keyszer G, Lein M, Kristiansen G, Schnorr D, Loening SA, Jung K.
Prostate 2003 May; 55(2):89.
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Matrix metalloproteinases.
Nagase H, Woessner JF Jr.
The Journal of Biological Chemistry 1999 Jul; 274(31):21491.
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Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA.
Matsumoto S, Katoh M, Saito S, Watanabe T, Masuho Y.
Biochimica et Biophysica Acta 1997 Nov; 1354(2):159.
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mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.
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