MLLT3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MLLT3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human MLLT3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The MLLT3 polyclonal antibody (Cat # PAB4770) is used in Western blot to detect MLLT3 in mouse cerebellum tissue lysateEnzyme-linked Immunoabsorbent Assay
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Gene Info — MLLT3
Entrez GeneID
4300Protein Accession#
NP_004520;P42568Gene Name
MLLT3
Gene Alias
AF9, FLJ2035, YEATS3
Gene Description
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
Omim ID
159558Gene Ontology
HyperlinkGene Summary
Drosophila); translocated to
Other Designations
OTTHUMP00000021127|OTTHUMP00000045120|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3
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Interactome
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Disease
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Publication Reference
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DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis.
Strissel PL, Strick R, Tomek RJ, Roe BA, Rowley JD, Zeleznik-Le NJ.
Human Molecular Genetics 2000 Jul; 9(11):1671.
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Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.
Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, et al..
PNAS 1993 May; 90(10):4631.
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DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis.
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