MLLT10 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of MLLT10 polyclonal antibody (Cat # PAB4767) in Jurkat cell lysate. MLLT10 (arrow) was detected using the purified polyclonal antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human testis tissue reacted with MLLT10 polyclonal antibody (Cat # PAB4767) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MLLT10.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human MLLT10.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MLLT10 polyclonal antibody (Cat # PAB4767) in Jurkat cell lysate. MLLT10 (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human testis tissue reacted with MLLT10 polyclonal antibody (Cat # PAB4767) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MLLT10
Entrez GeneID
8028Protein Accession#
NP_004632;P55197Gene Name
MLLT10
Gene Alias
AF10, DKFZp686E10210, MGC75086
Gene Description
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
Gene Ontology
HyperlinkGene Summary
Drosophila); translocated to
Other Designations
ALL-1 fused gene from chromosome 10|OTTHUMP00000019275|OTTHUMP00000045273|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 10|myeloid/lymphoid or mixed-lineage leukemia translocated to, 10|type I AF10 protein
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Interactome
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Disease
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Publication Reference
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The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions.
Perrin L, Bloyer S, Ferraz C, Agrawal N, Sinha P, Dura JM.
Molecular and Cellular Biology 2003 Jan; 23(1):119.
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ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E.
Molecular Cell 2002 Nov; 10(5):1119.
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Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia.
Roll P, Zattara-Cannoni H, Bustos-Bernard MC, Curtillet C, Michel G, Vagner-Capodano AM.
Cancer Genetics and Cytogenetics 2002 Jun; 135(2):187.
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The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions.
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