MAGEB2 polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of MAGEB2 (arrow) using MAGEB2 polyclonal antibody (Cat # PAB4752).
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAGEB2 gene (Lane 2).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with MAGEB2 polyclonal antibody (Cat # PAB4752) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAGEB2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MAGEB2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of MAGEB2 (arrow) using MAGEB2 polyclonal antibody (Cat # PAB4752).
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAGEB2 gene (Lane 2).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with MAGEB2 polyclonal antibody (Cat # PAB4752) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MAGEB2
Entrez GeneID
4113Protein Accession#
NP_002355Gene Name
MAGEB2
Gene Alias
DAM6, MAGE-XP-2, MGC26438
Gene Description
melanoma antigen family B, 2
Omim ID
300098Gene Ontology
HyperlinkGene Summary
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq
Other Designations
DSS/AHC critical interval MAGE superfamily 6|OTTHUMP00000023098|melanoma-associated antigen B2
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Interactome
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Publication Reference
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Hypertonicity induction of melanoma antigen, a tumor-associated antigen.
Park JH, Lee SW.
Molecules and Cells 2002 Apr; 13(2):288.
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Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins.
Lurquin C, De Smet C, Brasseur F, Muscatelli F, Martelange V, De Plaen E, Brasseur R, Monaco AP, Boon T.
Genomics 1997 Dec; 46(3):397.
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A family of rapidly evolving genes from the sex reversal critical region in Xp21.
Dabovic B, Zanaria E, Bardoni B, Lisa A, Bordignon C, Russo V, Matessi C, Traversari C, Camerino G.
Mammalian Genome 1995 Sep; 6(9):571.
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Hypertonicity induction of melanoma antigen, a tumor-associated antigen.
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