LEP polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LEP.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human LEP.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MDA-MB-231 cell lysate (35 ug/lane) with LEP polyclonal antibody (Cat # PAB4729).Enzyme-linked Immunoabsorbent Assay
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Gene Info — LEP
Entrez GeneID
3952Protein Accession#
NP_000221Gene Name
LEP
Gene Alias
FLJ94114, OB, OBS
Gene Description
leptin
Omim ID
164160Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq
Other Designations
leptin (murine obesity homolog)|leptin (obesity homolog, mouse)|obese, mouse, homolog of|obesity factor
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Interactome
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Pathway
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Disease
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Publication Reference
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Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance.
Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ.
European Journal of Endocrinology 2003 Oct; 149(4):331.
Application:RIA, Human, Human plasma.
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Bound leptin and sympathetic outflow in nonobese men.
Tank J, Jordan J, Diedrich A, Schroeder C, Furlan R, Sharma AM, Luft FC, Brabant G.
The Journal of Clinical Endocrinology and Metabolism 2003 Oct; 88(10):4955.
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C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol.
Kazumi T, Kawaguchi A, Hirano T, Yoshino G.
Metabolism: Clinical and Experimental 2003 Sep; 52(9):1113.
Application:ELISA, Human, Serum.
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Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance.
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