ICOS polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ICOS.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ICOS.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The ICOS polyclonal antibody (Cat # PAB4726) is used in Western blot to detect ICOS in HL-60 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with ICOS polyclonal antibody (Cat # PAB4726) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — ICOS
Entrez GeneID
29851Protein Accession#
NP_036224Gene Name
ICOS
Gene Alias
AILIM, CD278, MGC39850
Gene Description
inducible T-cell co-stimulator
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq
Other Designations
activation-inducible lymphocyte immunomediatory molecule|inducible costimulator
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Interactome
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Pathway
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Disease
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Publication Reference
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PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production.
Okamoto N, Tezuka K, Kato M, Abe R, Tsuji T.
Biochemical and Biophysical Research Communications 2003 Oct; 310(3):691.
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Expression and function of the co-stimulator H4/ICOS on activated T cells of patients with rheumatoid arthritis.
Okamoto T, Saito S, Yamanaka H, Tomatsu T, Kamatani N, Ogiuchi H, Uchiyama T, Yagi J.
The Journal of Rheumatology 2003 Jun; 30(6):1157.
Application:Flow Cyt, Func, Human, Human PBMCs, T cells.
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Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors.
Riley JL, Mao M, Kobayashi S, Biery M, Burchard J, Cavet G, Gregson BP, June CH, Linsley PS.
PNAS 2002 Sep; 99(18):11790.
Application:Bead, Recombinant protein.
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PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production.
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