LPAR1 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
The LPAR1 polyclonal antibody (Cat # PAB4719) is used in Western blot to detect LPAR1 in A-375 cell lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LPAR1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human LPAR1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The LPAR1 polyclonal antibody (Cat # PAB4719) is used in Western blot to detect LPAR1 in A-375 cell lysate.Enzyme-linked Immunoabsorbent Assay
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Gene Info — LPAR1
Entrez GeneID
1902Protein Accession#
NP_001392Gene Name
LPAR1
Gene Alias
EDG2, GPR26, Gpcr26, LPA1, Mrec1.3, VZG1, edg-2, rec.1.3, vzg-1
Gene Description
lysophosphatidic acid receptor 1
Omim ID
602282Gene Ontology
HyperlinkGene Summary
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq
Other Designations
OTTHUMP00000021903|OTTHUMP00000021904|OTTHUMP00000021905|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2|ventricular zone gene 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Structure-based discovery of a subtype-selective inhibitor targeting a transient receptor potential vanilloid channel.
Chai H, Cheng X, Zhou B, Zhao L, Lin X, Huang D, Lu W, Lv H, Tang F, Zhang Q, Huang W, Li Y, Yang H.
Journal of Medicinal Chemistry 2019 Feb; 62(3):1373.
Application：WB, Human, PC-3M cells.
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The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases.
Boucharaba A, Serre CM, Guglielmi J, Bordet JC, Clezardin P, Peyruchaud O.
PNAS 2006 Jun; 103(25):9643.
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Structure-based discovery of a subtype-selective inhibitor targeting a transient receptor potential vanilloid channel.
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