XIAP polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of XIAP.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human XIAP.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The XIAP polyclonal antibody (Cat # PAB4709) is used in Western blot to detect XIAP in mouse liver tissue lysate.Western Blot (Cell lysate)
Western blot analysis of XIAP polyclonal antibody (Cat # PAB4709) in Ramos cell lysate (35 ug/lane). XIAP (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with XIAP polyclonal antibody (Cat # PAB4709) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.Enzyme-linked Immunoabsorbent Assay
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Gene Info — XIAP
Entrez GeneID
331Protein Accession#
NP_001158;P98170Gene Name
XIAP
Gene Alias
API3, BIRC4, ILP1, MIHA, XLP2
Gene Description
X-linked inhibitor of apoptosis
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. This protein inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. It also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. [provided by RefSeq
Other Designations
OTTHUMP00000023975|OTTHUMP00000196392|apoptosis inhibitor 3|baculoviral IAP repeat-containing 4|baculoviral IAP repeat-containing protein 4
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Interactome
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Pathway
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Disease
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Publication Reference
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The gene expression profile of human umbilical vein endothelial cells stimulated with lipopolysaccharide using cDNA microarray analysis.
Ahn SK, Choe TB, Kwon TJ.
International Journal of Molecular Medicine 2003 Aug; 12(2):231.
Application:WB, Human, HUVECs.
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Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES.
The Journal of Biological Chemistry 2003 Aug; 278(34):31469.
Application:WB-Tr, Human, HEK 293 cells.
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Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells.
Miranda MB, Dyer KF, Grandis JR, Johnson DE.
Leukemia 2003 Feb; 17(2):390.
Application:WB, Human, HL-60 cells.
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The gene expression profile of human umbilical vein endothelial cells stimulated with lipopolysaccharide using cDNA microarray analysis.
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