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Last updated: 2017/9/24
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BACE2 polyclonal antibody

  • Catalog # : PAB4706
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of BACE2.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to internal region of human BACE2.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Recommend Usage:
  • ELISA (1:1000)
    Western Blot (1:100-500)
    Flow cytometry (1:10-50)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • 2.
  • BACE-2 is overexpressed in Down's syndrome.
    Barbiero L, Benussi L, Ghidoni R, Alberici A, Russo C, Schettini G, Pagano SF, Parati EA, Mazzoli F, Nicosia F, Signorini S, Feudatari E, Binetti G.Exp Neurol. 2003 Aug;182(2):335-45.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • The BACE2 polyclonal antibody (Cat # PAB4706) is used in Western blot to detect BACE2 in HL-60 cell lysate.
  • ELISA
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of HL-60 cells using BACE2 polyclonal antibody (Cat # PAB4706)(bottom histogram) compared to a negative control cell (top histogram).
    FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Gene Name:
  • BACE2
  • Gene Alias:
  • AEPLC,ALP56,ASP1,ASP21,BAE2,CDA13,CEAP1,DRAP
  • Gene Description:
  • beta-site APP-cleaving enzyme 2
  • Gene Summary:
  • Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
  • Other Designations:
  • 56 kDa aspartic-like protease,Down syndrome region aspartic protease,aspartyl protease 1,beta secretase 2,beta-site amyloid beta A4 precursor protein-cleaving enzyme 2,memapsin-1,membrane-associated aspartic protease 1,transmembrane aspartic proteinase As
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