Products

Western Blot (Cell lysate)

The BACE2 polyclonal antibody (Cat # PAB4694) is used in Western blot to detect BACE2 in A-549 cell lysate.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with BACE2 polyclonal antibody (Cat # PAB4694) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

25825

Protein Accession#

Q9NZL2

Gene Name

BACE2

Gene Alias

AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP

Gene Description

beta-site APP-cleaving enzyme 2

Omim ID

605668

Gene Ontology

Hyperlink

Gene Summary

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq

Other Designations

56 kDa aspartic-like protease|Down syndrome region aspartic protease|aspartyl protease 1|beta secretase 2|beta-site amyloid beta A4 precursor protein-cleaving enzyme 2|memapsin-1|membrane-associated aspartic protease 1|transmembrane aspartic proteinase As