CA9 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CA9.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human CA9.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The CA9 polyclonal antibody (Cat # PAB4679) is used in Western blot to detect CA9 in Jurkat cell lysate.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CA9
Entrez GeneID
768Protein Accession#
NP_001207;Q16790Gene Name
CA9
Gene Alias
CAIX, MN
Gene Description
carbonic anhydrase IX
Omim ID
603179Gene Ontology
HyperlinkGene Summary
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq
Other Designations
OTTHUMP00000022773|RCC-associated protein G250|carbonic dehydratase
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Interactome
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Pathway
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Disease
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Publication Reference
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Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma.
Grabmaier K, A de Weijert MC, Verhaegh GW, Schalken JA, Oosterwijk E.
Oncogene 2004 Jul; 23(33):5624.
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DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.
Kaluzova M, Kaluz S, Lerman MI, Stanbridge EJ.
Molecular and Cellular Biochemistry 2004 Jul; 24(13):5757.
Application:WB, Human, MCF-7, Saos-2 cells.
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Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome.
Span PN, Bussink J, Manders P, Beex LV, Sweep CG.
British Journal of Cancer 2003 Jul; 89(2):271.
Application:IHC-Fr, Human, Breast tumour.
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Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma.
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