Products

Western Blot (Tissue lysate)

The CKMT1A polyclonal antibody (Cat # PAB4614) is used in Western blot to detect CKMT1A in mouse colon tissue lysate .

Western Blot (Cell lysate)

The CKMT1A polyclonal antibody (Cat # PAB4614) is used in Western blot to detect CKMT1A in ZR-75-1 cell lysate .

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

548596

Protein Accession#

P12532

Gene Name

CKMT1A

Gene Alias

CKMT1, FLJ50967, UMTCK

Gene Description

creatine kinase, mitochondrial 1A

Gene Ontology

Hyperlink

Gene Summary

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq

Other Designations

OTTHUMP00000066270|OTTHUMP00000066271|acidic-type mitochondrial creatine kinase|creatine kinase, mitochondrial 1 (ubiquitous)