PRKAR2B polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of PRKAR2B polyclonal antibody (Cat # PAB4582) in mouse brain tissue lysate . PRKAR2B (arrow) was detected using purified PRKAR2B polyclonal antibody (Cat # PAB4582) . Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PRKAR2B.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 32-62 at N-terminus of human PRKAR2B.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Saturated ammonium sulfate precipitation
Recommend Usage
ELISA
Western Blot (~1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide).
Storage Instruction
Store at 4°C for up to 2 weeks. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of PRKAR2B polyclonal antibody (Cat # PAB4582) in mouse brain tissue lysate . PRKAR2B (arrow) was detected using purified PRKAR2B polyclonal antibody (Cat # PAB4582) . Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence .Enzyme-linked Immunoabsorbent Assay
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Gene Info — PRKAR2B
Entrez GeneID
5577Protein Accession#
KAP3_HUMAN; P31323Gene Name
PRKAR2B
Gene Alias
PRKAR2, RII-BETA
Gene Description
protein kinase, cAMP-dependent, regulatory, type II, beta
Omim ID
176912Gene Ontology
HyperlinkGene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq
Other Designations
H_RG363E19.2|WUGSC:H_RG363E19.2|cAMP-dependent protein kinase type II-beta regulatory chain|cAMP-dependent protein kinase, regulatory subunit beta 2
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Interactome
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Pathway
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Publication Reference
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Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3'-5'-cyclic adenosine monophosphate-dependent protein kinase from human testis.
Levy FO, Oyen O, Sandberg M, Tasken K, Eskild W, Hansson V, Jahnsen T.
Molecular Endocrinology (Baltimore, Md.) 1988 Dec; 2(12):1364.
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Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3'-5'-cyclic adenosine monophosphate-dependent protein kinase from human testis.
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