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Last updated: 2016/10/23
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PRKAR2B polyclonal antibody

  • Catalog # : PAB4582
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of PRKAR2B.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PRKAR2B.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Recommend Usage:
  • ELISA (1:1000)
    Western Blot (1:100-500)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of PRKAR2B polyclonal antibody (Cat # PAB4582) in mouse brain tissue lysate . PRKAR2B (arrow) was detected using purified PRKAR2B polyclonal antibody (Cat # PAB4582) . Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence .
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5577
  • Gene Name:
  • Gene Alias:
  • Gene Description:
  • protein kinase, cAMP-dependent, regulatory, type II, beta
  • Gene Summary:
  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq
  • Other Designations:
  • H_RG363E19.2,WUGSC:H_RG363E19.2,cAMP-dependent protein kinase type II-beta regulatory chain,cAMP-dependent protein kinase, regulatory subunit beta 2
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